Previous study reported the presence of anti-inflammatory constituents in Anisomeles indica & Anisomeles malabarica, separately. First time for Anisomeles species, the comparative studies are carried out here for the mentioned activity. The constituents are β- sitosterol (AIC-1), stigmasterol (AMC-1), ovatodiolide (AIE-1 & AME-1), quercetin (AIM-1 & AMM-1) and catechin (AIAc-1 & AMAc-1) isolated from Anisomeles species. The identification of isolated compounds was carried out by various physical, chemical and instrumental techniques. The presence of stigmasterol in A. malabarica differs from the A.indica, which consist β- sitosterol. In-vitro anti-inflammatory models were studied; as inhibition of protein denaturation, effect of membrane stabilization of human RBC. The methanolic herbal extracts of A. malabarica shows strong anti-inflammatory activity at different concentration. The herbal extract showed dose dependent activity, when compare to acetyl salicylic acid and, hydrocortisone as a standard.
Loading....